2016 Fiscal Year Final Research Report
The evaluation of suppressive effects for suppression of tumor metastasis using retrovirally introduced antitumor cytokine, IL-24 into prostate cancer cells.
Project/Area Number |
26430169
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Tumor therapeutics
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Research Institution | Kitasato University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Keywords | インターロイキン24 / 抗腫瘍性サイトカイン |
Outline of Final Research Achievements |
In this study, antitumor effects such as cell proliferation inhibition, apoptosis induction and epithelial marker elevation, were significantly observed in retrovirally IL-24 introduced into prostate cancer defecting IL-24 receptors. Interestingly, those effects were not observed by administration of recombinant IL-24 to the prostate cancer cells. The detail of mechanism for the antitumor effects by introduced IL-24 may dissolve in the future.
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Free Research Field |
総合領域
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