2016 Fiscal Year Final Research Report
Mechanism of Ph positive leukemia cell maintenance by Hippo pathway
| Project/Area Number |
26430171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor therapeutics
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
Okabe Seiichi 東京医科大学, 医学部, 講師 (40366109)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | AMPK |
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| Outline of Final Research Achievements |
We made BCR-ABL positive iPS cells and analyze the phenotype, cell proliferation and efficacy of ABL inhibitors in iPS cells. Because the association between AMPK and Hippo pathway has been reported, we investigated the effect of AMPK on Ph-positive leukemia. Pioglitazone induced cell growth inhibition in a concentration-dependent manner in Ph-positive leukemia cells and enhanced AMPK phosphorylation. Co-treatment with pioglitazone and ABL inhibitor decreased the expression of BCR-ABL in CML patient. Pioglitazone may possess promising clinical relevance as a candidate therapeutic agent for Ph-positive leukemia in the future.
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| Free Research Field |
血液腫瘍学
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