アジュバント機能が包含された人工タンパク質抗原を用いたがんワクチンの開発

Products Report

• Project/Area Number: 26430172
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Jikei University School of Medicine
• Principal Investigator: Masaki Ito 東京慈恵会医科大学, 医学部, 講師 (80297366)
• Co-Investigator(Kenkyū-buntansha): 本間 定 東京慈恵会医科大学, 医学部, 教授 (50192323) ; 小井戸 薫雄 東京慈恵会医科大学, 医学部, 准教授 (70266617)
• Co-Investigator(Renkei-kenkyūsha): SHIBA KIYOTAKA がん研究所, 蛋白創製研究部, 部長 (40196415)
• Project Period (FY): 2014-04-01 – 2017-03-31

Research Products

• [Journal Article] Encryption of agonistic motifs for TLR4 into artificial antigens augmented the maturation of antigen-presenting cells. (2017)
  • Author(s): Ito M, Hayashi K, Minamisawa T, Homma S. Koido S, Shiba K
  • Journal Title: PLoS ONE Volume: 12(11) : e0188934
  • DOI: 10.1371/journal.pone.0188934
  • Peer Reviewed / Open Access
• [Journal Article] Combinatorial Contextualization of Peptidic Epitopes for Enhanced Cellular Immunity. (2014)
  • Author(s): Ito M, Hayashi K, Adachi E, Minamisawa T, Homma S, Koido S, Shiba K
  • Journal Title: PLoS ONE Volume: 9(10) : e110425
  • DOI: 10.1371/journal.pone.0110425
  • Peer Reviewed / Open Access
• [Presentation] Artificial antigen appended with TLR-4 agonist peptide motif stimulates cytokine production of antigen-presenting cells. (2016)
  • Author(s): 伊藤正紀
  • Organizer: 第75回日本癌学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県横浜市)
  • Year and Date: 2016-10-07
• [Presentation] Encrypted peptidic ligand for TLR-4 augmented the cellular immunity of artificial proteinous antigens. (2015)
  • Author(s): 伊藤正紀
  • Organizer: 第74回日本癌学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-10-10
• [Patent(Industrial Property Rights)] 細胞性免疫誘導ワクチン (2014)
  • Inventor(s): 伊藤正紀、芝 清隆
  • Industrial Property Rights Holder: 学校法人慈恵大学、公益財団法人がん研究会
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: PCT/JP2014/67355
  • Filing Date: 2014-06-30
  • Overseas