Functional analysis of a novel breast cancer related protein: EphA10 for development of anti-EphA10 antibody drugs in refractory breast cancer cases

2016 Fiscal Year Final Research Report

• Project/Area Number: 26430180
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Osaka University (2015-2016); 独立行政法人医薬基盤研究所 (2014)
• Principal Investigator: NAGANO Kazuya 大阪大学, 薬学研究科, 准教授 (40548301)
• Research Collaborator: TSUNODA Shin-ichi ; KAMADA Haruhiko ; MIYOSHI Jun ; OKAMOTO Miki ; NISHIZAWA Kyoko ; MATSUDA Jun-ichiro ; MUKAI Yohei ; TSUTSUMI Yasuo ; YOSHIOKA Yasuo
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: Eph receptor A10 / 抗体療法 / アカデミア創薬

Outline of Final Research Achievements

The purpose of this research is to reveal the EphA10 function in both breast cancer tissues and normal tissues, for development of an anti-EphA10 antibody drug in refractory breast cancer cases. The function analysis of EphA10 in breast cancer cells showed that EphA10 promoted breast cancer cell proliferation, suggesting that Clone: LBR inhibited tumor growth by CDC or neutralizing activity. On the other hand, the function analysis of EphA10 in testis tissues showed that EphA10 might inhibit the tissue growth and testosterone secretion. Furthermore, we could successfully isolate human anti-EphA10 monoclonal antibody candidates for clinical trials. Consequently, we hope that the findings contribute to the development of effective and safe antibody drugs.

Free Research Field

動態学