2016 Fiscal Year Final Research Report
Analysis of genetic variation in repetitive and non-reference genomic regions
| Project/Area Number |
26430196
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical genome science
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| Research Institution | Kyoto University (2016)
Institute of Physical and Chemical Research (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 次世代シークエンサー / ヒトゲノム多様性 |
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| Outline of Final Research Achievements |
Recent progress of DNA sequencing technology enables us to sequence whole genome. However, read length of the current DNA sequencers are short, and therefore repetitive regions and non-reference genomic regions can not be analyzed. To examine the polymorphism of repetitive regions and non-reference genomic regions, we collected unmapped reads from human whole genome sequence data, and designed capture probes to obtain DNA from these regions. We sequenced the collected DNA with a long read sequencing technology. We identified genetic variation in the repetitive and non-reference genomic regions.
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| Free Research Field |
人類遺伝学
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