2016 Fiscal Year Final Research Report
Elucidating the folding principles of the human genome
| Project/Area Number |
26440010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | Waseda University |
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Principal Investigator |
Ohyama Takashi 早稲田大学, 教育・総合科学学術院, 教授 (60268513)
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| Research Collaborator |
YONEYAMA Hiroki
YOSHIDA Kai
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ヒトゲノムDNA / ゲノムフォールディング / 染色体構築 / 間期染色体 / 分裂期染色体 |
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| Outline of Final Research Achievements |
The purpose of this study is to elucidate the folding principles of the human genome. Based on the simulation of a chromatin loop structure in the chromosome 21 and subsequent comparison between the resulting model and the actual structure, we obtained a clue to the elucidation of the principles. It was strongly suggested that the fundamental structure of a chromatin loop is presumably determined by nucleosome positioning, conformations of linker DNAs, distance between the loop anchors and self-assembly of the nucleosomes with identical DNA sequences.
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| Free Research Field |
分子生物学
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