2016 Fiscal Year Final Research Report
Novel conjugation of the ubiquitin-like protein Atg8 and its biological significance
| Project/Area Number |
26440052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Osaka University |
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Principal Investigator |
OKAMOTO Noriko 大阪大学, 生命機能研究科, 特任講師(常勤) (90568750)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMOTO Koji 大阪大学, 生命機能研究科, 准教授 (40455217)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Atg8 / ユビキチン様タンパク質 / オートファジー / 翻訳後修飾 / タンパク質分解 |
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| Outline of Final Research Achievements |
Atg8 is a phospholipid-conjugated ubiquitin-like protein essential for autophagy. Using budding yeast, this study demonstrated that Atg8 is also conjugated to several proteins under selective mitochondrial degradation-inducing conditions. In addition, Asu1 (Atg8ylation substrate 1), an endoplasmic reticulum membrane protein, has been identified as a substrate for Atg8 conjugation. It is possible that Atg8ylation contributes to autophagy-dependent degradation of Asu1.
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| Free Research Field |
細胞生物学
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