Molecular mechanism of TORC1 activity and function in meiosis using a model organism.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26440053
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Kobe University
• Principal Investigator: Nakashima Akio 神戸大学, バイオシグナル総合研究センター, 准教授 (70397818)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: TORC1 / 減数分裂 / シグナル伝達 / モデル生物 / 分裂酵母

Outline of Final Research Achievements

The Target of rapamycin complex 1 (TORC1) protein kinase plays a critical role of several cellular controls in response to environmental inputs, including nutrients. In this study, we examined the mechanism of TORC1 regulation and its functions during meiosis even under nitrogen starvation using a model organism, the fission yeast Schizosaccharomyces pombe. We showed that TORC1 activity is substantially increased when cells enter meiotic phase under nitrogen starvation and two molecules involving meiotic progression are important for the TORC1 regulation in meiosis. TORC1 was required for meiotic progression though the regulation of gene transcription. The findings obtained in this study propose a novel molecular model of the regulation and function of TORC1 in meiosis in a wide range of eukaryotic organisms.

Free Research Field

細胞内シグナル伝達，分子遺伝学