2017 Fiscal Year Final Research Report
Characterization of golgins in secretion and Golgi
| Project/Area Number |
26440055
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Functional biochemistry
|
|---|
| Research Institution | Okayama University |
|---|
Principal Investigator |
Satoh Ayano 岡山大学, 自然科学研究科, 准教授 (40303002)
|
|---|
| Research Collaborator |
Nishino Kunihiko
Nishino Mitsuko (Hayashi Mitsuko)
Nishina Yuta
Yu Sidney
|
|---|
| Project Period (FY) |
2014-04-01 – 2018-03-31
|
| Keywords | ゴルジ体 / 分泌 / 電子線トモグラフィー / ノックダウン / ゴルジン / 小分子化合物 |
|---|
| Outline of Final Research Achievements |
We have shown that secretion increases and the structure of the Golgi changes when knocking down giantin, which is one of the Golgin protein group. In this research project, to clarify the molecular mechanisms underlying this phenomenon as the ultimate goal, the structure of the Golgi was analyzed in detail using electron beam tomography and the like. Also, during this time, we discovered a novel small molecule involved in secretion regulation, so we performed the characterization of new molecules, as well.
|
| Free Research Field |
細胞生物学
|
