The analysis of the molecular mechanism of amphibian metamorphosis using genomic editing

2017 Fiscal Year Final Research Report

• Project/Area Number: 26440057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Hiroshima University
• Principal Investigator: Yaoita Yoshio 広島大学, 両生類研究センター, 教授 (00166472)
• Co-Investigator(Kenkyū-buntansha): 田澤 一朗 広島大学, 両生類研究センター, 助教 (10304388) ; 中島 圭介 広島大学, 両生類研究センター, 助教 (60260311)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: 変態 / 甲状腺ホルモン / 両生類 / げっ歯類 / 脳の変態 / 肝臓の変態 / 出生 / ネッタイツメガエル

Outline of Final Research Achievements

We have examined whether the birth of the mammalian newborn corresponds to metamorphosis. In rodent, the surge of thyroid hormone is observed in the first three postnatal weeks. Eleven genes up-regulated in the brain of Xenopus tropicalis during metamorphosis were analyzed in detail and their expression levels increased in the rodent brain during three postnatal weeks. The expression of six genes encoding proteins up-regulated in mouse brain during the three postnatal weeks was also induced in the tadpole brain during metamorphosis. These data indicate that the similar gene expression profile to that of metamorphosing tadpole brain was elicited in rodent brain and strongly suggested that the rodent brain undergoes metamorphosis.

Free Research Field

発生生物学