The function of acidic organelles in signal transduction

2016 Fiscal Year Final Research Report

• Project/Area Number: 26440068
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Doshisha Women's College of Liberal Arts
• Principal Investigator: Sun-Wada Ge-Hong (孫戈虹) 同志社女子大学, 薬学部, 教授 (00314427)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: V-ATPase / Cancer

Outline of Final Research Achievements

The vacuolar-type proton ATPases (V-ATPases) are a family of ATP-driven proton pumps that acidify intracellular compartments and transport protons across the plasma membrane. We have shown that the a3 subunit of V-ATPase was involved in human breast cancer invasion.
We have also shown that we show that proton released via V-ATPase by bone-resorbing OCLs and JJN3 MM cells create an acidic bone microenvironment that excites sensory neurons innervating bone via activation of ASIC3 to induce multiple myeloma bone pain. Further, blocking the generation of the acidic bone microenvironment and the activation of ASIC3 on sensory neurons significantly reduced multiple myeloma bone pain and could be a mechanism-based therapeutic approach for multiple myeloma bone pain.

Free Research Field

分子細胞生物学