2016 Fiscal Year Final Research Report
Study of the structural and functional diversities of vertebrate cilia
| Project/Area Number |
26440094
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
NARITA Keishi 山梨大学, 総合研究部, 准教授 (50452131)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 繊毛 |
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| Outline of Final Research Achievements |
A novel gene involved in the proper formation of vertebrate cilia was identified and characterized. The knockout mouse demonstrated a severe phenotype after birth due to defects in ciliogenesis. Transmission electron microscopy of the affected organs revealed that the integrity of axonemal arrangement and number were lost in the null mutant. Although there is no clinical report related to this gene, SNP analysis suggested the existence of SNPs that would lead to the loss of function of this gene.
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| Free Research Field |
細胞生物学
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