2016 Fiscal Year Final Research Report
Molecular basis of nuclear structures regulated by nuclear pore complex proteins
| Project/Area Number |
26440098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Research Collaborator |
HIRAOKA Yasushi
ZHANG Xu
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 核膜孔複合体 / 核構造 / 分裂酵母 / 核膜 |
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| Outline of Final Research Achievements |
We found that a non-essential nuclear pore complex protein Nup132 is essential for establishment of kinetochore structure and for attachment of kinetochore and microtubule in the meiotic first division, firstly indicating that the nuclear pore complex participates in the meiotic chromosome segregation. Next, we revealed a specific but dispensable regulation for expressions of nuclear pore complex proteins Nup98 and Nup96. We also found that an inner nuclear membrane protein Lem2 is essential for centromere-specific heterochromatin formation. In addition, we developed a novel fluorescent probe to visualize histone modification.
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| Free Research Field |
分子遺伝学 細胞生物学
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