Studies on stress response mechanism of target of rapamycin complex 2

2016 Fiscal Year Final Research Report

• Project/Area Number: 26440099
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Nara Institute of Science and Technology
• Principal Investigator: MORIGASAKI Susumu 奈良先端科学技術大学院大学, バイオサイエンス研究科, 博士研究員 (90242487)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ターゲットオブラパマイシン / 分裂酵母 / シグナル伝達 / ストレス応答 / 低分子量型Gタンパク質 / MAPキナーゼ

Outline of Final Research Achievements

Target of rapamycin (TOR) is a kinase that regulates metabolism, proliferation and growth in response to nutrients, stresses etc. TOR forms two different protein complexes, TORC1 and TORC2. On the contrary to TORC1, little was known about the regulation mechanism of TORC2 in any organisms. Since my colleagues and I already had isolated some candidates of the TORC2 regulators in the fission yeast, Schizosaccharomyces pombe, this research project has focused on the regulation mechanism of TORC2 by the candidates. The results obtained in this project indicate that the candidates mediate different stimuli to TORC2 and regulate TORC2 in the different manners. A part of the results showing that a small GTPase Ryh1 mediates glucose signal to TORC2 was disclosed by publishing a research article. The results highlight stress response mechanism of TORC2 and will facilitate investigation of human TORC2.

Free Research Field

生物学