Nobel signaling mechanisms for insulin-dependent glucose uptake in skeletal muscle

2016 Fiscal Year Final Research Report

• Project/Area Number: 26440103
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Osaka Prefecture University
• Principal Investigator: Satoh Takaya 大阪府立大学, 理学(系)研究科(研究院), 教授 (20251655)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: インスリン / 骨格筋 / GTP結合蛋白質 / Rac1

Outline of Final Research Achievements

Insulin regulates the blood glucose level by inducing glucose uptake in skeletal muscle. In this study, we aimed to reveal the role and regulatory mechanisms of the small GTPase Rac1 in insulin-dependent glucose uptake in skeletal muscle by using mouse models. We identified a novel signaling mechanism whereby the guanine nucleotide exchange factor FLJ00068 activates Rac1 downstream of phosphoinositide 3-kinase and the serine/threonine protein kinase Akt2. Furthermore, we found that the small GTPase RalA regulates glucose uptake downstream of Rac1 in skeletal muscle.

Free Research Field

細胞内シグナル伝達