2016 Fiscal Year Final Research Report
Functional analysis of a novel PCP regulator
| Project/Area Number |
26440113
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Akita University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 平面内細胞極性 / PCP / 発生生物学 / 遺伝学 |
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| Outline of Final Research Achievements |
Most tissues and organs acquire a polarity within the plane of the epithelium, which is orthogonal to the axis of apico-basal polarity. This is called planar cell polarity (PCP). PCP pathway is an evolutionarily conserved mechanism in multicellular organism.
PCP molecules are categorized into two groups by its function. In previous study we have already succeeded to find a novel group of PCP regulators (Jbug group). In this study we try to understand molecular mechanism by which Jbug group regulates the PCP pathway.
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| Free Research Field |
発生生物学
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