2016 Fiscal Year Final Research Report
Mechanisms of male-type differentiation in mouse primordial germ cells
| Project/Area Number |
26440120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Yokohama National University |
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Principal Investigator |
Suzuki Atsushi 横浜国立大学, 大学院工学研究院, 准教授 (60467058)
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| Research Collaborator |
NIIMI Yuki
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 生殖細胞 / Nanos / Dead end |
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| Outline of Final Research Achievements |
Mouse NANOS2 suppresses ectopic meiosis and promotes male-type gene expression, playing a critical role in sexual differentiation of primordial germ cells. However, the mechanisms involved in target specificity remain elusive. We show that another RBP, Dead end1 (DND1), directly interacts with NANOS2 to load unique RNAs into the CNOT complex. Thus, DND1 is an essential partner for NANOS2 that leads to the degradation of specific RNAs.
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| Free Research Field |
発生生物学、細胞生物学
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