2017 Fiscal Year Final Research Report
Analysis of the molecular mechanisms downstream of Pitx2 and left-right asymmetric morphogenesis.
| Project/Area Number |
26440124
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kyoto Sangyo University (2016-2017)
Osaka University (2014-2015) |
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Principal Investigator |
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| Research Collaborator |
HAMADA Hiroshi
MINEGISHI Katsura
IKAWA Yayoi
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 左右非対称 / 器官形成 / Pitx2 / 四肢形成 / 細胞外マトリックス |
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| Outline of Final Research Achievements |
About left-right asymmetric morphogenesis in visceral organs and limb, I discovered the following molecular mechanisms:
(1)In the limb, Pitx2 regulates left-right asymmetric morphogenesis. It was suggested that asymmetric morphogenesis may be involved in human handedness.
(2)LR1, a extracellular matrix factor, is involved in left-right asymmetric morphogenesis. It was suggested that the extracellular matrix is important for the left-right asymmetric morphogenesis.
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| Free Research Field |
発生生物学
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