Analysis of Hedgehog signaling-mediated regulation of cell dynamics in the early embryo

2017 Fiscal Year Final Research Report

• Project/Area Number: 26440130
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Osaka Medical College (2015-2017); JT Biohistory Research Hall (2014)
• Principal Investigator: Akiyama-Oda Yasuko (秋山康子) 大阪医科大学, 医学部, 非常勤講師 (80426650)
• Research Collaborator: ODA Hiroki 株式会社生命誌研究館, 主任研究員 (50396222)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: ゲノム / 遺伝子発現 / 初期発生 / ヘッジホッグシグナル

Outline of Final Research Achievements

Hedgehog signaling has an important role in various developmental events. In the embryo of the spider Parasteatoda tepidariorum, Hedgehog signaling regulates early developmental events, such as anterior-posterior patterning, orientation of the dorsal-ventral axis, and morphogenesis. In this study, we performed genome-wide searches to identify target genes of Hedgehog signaling. We combined RNAi and RNA-seq techniques and identified many target genes that show region-specific expression in the early embryo. One of the identified genes, msh is found to be involved in segmentation and formation of the germ band.

Free Research Field

発生生物学