2016 Fiscal Year Final Research Report
Roles of transcription factor Runx 3 in ovarian follicle development and ovulation in mice
| Project/Area Number |
26440167
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUKAMACHI Hiroshi 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (70134450)
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| Research Collaborator |
TAKEUCHI Sakae
SAKUMA Atsuko
TSUCHIYA Yukiko
SAITO Yuka
OGO Yuki
OJIMA Fumiya
HAYASHI Sayo
KAYO Daichi
MAEKAWA Tetsuya
GU TinTin
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 排卵 / 卵巣 / ステロイホルモン / マウス / 成長因子 / 転写因子 |
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| Outline of Final Research Achievements |
The present study was aimed at clarifying the roles of transcription factor Runx3 in female mice. Runx3 mRNA was detected in the granulosa cells of ovaries, and in the neural cells in hypothalamic areas involved in regulation of ovulation in female mice. In Runx3 knockout female mice, hypothalamic Kisspeptin mRNA and ovarian cholesterol side-chain cleavage enzyme gene mRNA expressions were decreased. Dysfunction of hypothalamic regulatory mechanism of ovulation in Runx3 knockout female mice was demonstrated. These findings clearly suggest that Runx3 was involved in the regulation of ovarian steroid hormone production and hypothalamic ovulatory function.
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| Free Research Field |
分子内分泌学
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