2016 Fiscal Year Final Research Report
Amphibian hematopoietic regulation under environmental stress
| Project/Area Number |
26440171
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Waseda University |
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Principal Investigator |
Kato Takashi 早稲田大学, 教育・総合科学学術院, 教授 (80350388)
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| Research Collaborator |
KUROKI Ryota
MAEKAWA Shun
NAGASAWA Kazumichi
OKUI Takehito
TANIZAKI Yuta
SATO Kei
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 造血 / 血球 / アフリカツメガエル / ネッタイツメガエル / 環境ストレス / 造血因子 / 幹細胞 / プロテオミクス |
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| Outline of Final Research Achievements |
To develop a better comprehension of diversity and universality in vertebrate physiological regulations, we focus on amphibian hematopoietic responses against environmental stress in African clawed frog (Xenopus laevis) and Western clawed frog (Xenopus (Silurana) tropicalis). We established an in vivo Xenopus hypoxic model that caused a pulmonary defect. This model should be vital to investigate non-hematopoietic functions of erythropoietin. In the latter model, low-temperature exposure induced pancytopenia. We revealed that one of the causes of thrombocytopenia was due to the reversible cellular adhesion between thrombocytes and the vascular wall cells.
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| Free Research Field |
実験血液学，分子生理学
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