2017 Fiscal Year Final Research Report
Analysis for cell proliferation, differentiation and tumorigenesis in female reproductive tracts in mice
| Project/Area Number |
26440173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | Wakayama Medical University (2016-2017)
Okazaki Research Facilities, National Institutes of Natural Sciences (2014-2015) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | 膣 / エストロゲン / マウス / ホルモン |
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| Outline of Final Research Achievements |
The female reproductive tract consists of the sites for reproduction and is of significant concern for women’s health and disease, notably tumorigenesis. Despite the importance of this organ system, the molecular and cellular mechanisms that regulate cell proliferation and differentiation of these organs are not yet fully understood. In this analysis, we analyzed tissue-specific roles of estrogen receptors and showed that epithelial estrogen receptor 1 intrinsically mediates squamous differentiation in the mouse vagina. We also identified several growth factors, including epidermal growth factors (EGFs) and fibroblast growth factors (Fgfs), are involved in terminal differentiation of vaginal epithelial cells.
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| Free Research Field |
発生内分泌学
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