2017 Fiscal Year Final Research Report
Reconstructed synchronous oscillatory network in olfactory center of the slug
| Project/Area Number |
26440183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Keywords | synchronous oscillation / olfactory center / slug / cultured neuron |
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| Outline of Final Research Achievements |
Synchronous oscillatory activity in a laminar structure is common in the central nervous system of both vertebrates and invertebrates. In the terrestrial slugs, periodic oscillation is recorded from the surface of the laminar structure of procerebrum (PC), olfactory center, and its frequency changes are suggested to encode the olfactory information and memory. We found that in vitro oscillatory neuronal network was formed from dispersed cell culture of PC neurons. Nicotine or acetylcholine esterase inhibitor induced synchronous oscillatory activity in the culture networks. Previous our studies show acetylcholine increased frequency of LFP oscillation in the PC may be via nicotinic ACh receptors. These results suggest cholinergic system can function as a major chemical transmitter in cultured PC neuron network. It may play an essential role, such as driving force for synchronous oscillation in the olfactory neuron network.
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| Free Research Field |
神経生理学
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