Epigenetic inheritance caused by paternal restraint stress in Drosophila

2016 Fiscal Year Final Research Report

• Project/Area Number: 26440192
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Genetics/Chromosome dynamics
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Seong Ki-Hyeon 国立研究開発法人理化学研究所, 石井分子遺伝学研究室, 協力研究員 (40425632)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 拘束ストレス / ショウジョウバエ / エピジェネティクス / エピジェネティク遺伝 / dATF-2

Outline of Final Research Achievements

At present, the experimental evidences of epigenetic inheritance caused by stresses are beginning to accumulate in some animal models. However, molecular mechanism and biological meaning underlying these phenomena has not been clearly understood yet. We have established a new experimental system for analyzing epigenetic effects of drosophila exposed to restraint stress (RS). We observed that Drosophila F1 progenies, derived from RS exposed fathers, showed significant disruption of heterochromatin state and reduced energy metabolic rate. We also found that p38-dATF-2 pathway might play a central role for the epigenetic inheritance induced by RS.

Free Research Field

エピジェネティクス