Integration process of microRNAs into gene regulatory network and its evolution.

2017 Fiscal Year Final Research Report

• Project/Area Number: 26440197
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Evolutionary biology
• Research Institution: Kagawa University
• Principal Investigator: Iwama Hisakazu 香川大学, 総合生命科学研究センター, 准教授 (20398035)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: マイクロRNA / 哺乳類 / ターゲット遺伝子 / 遺伝子制御網

Outline of Final Research Achievements

Based on publicly available by-organ human transcriptome data sets and exhaustive microRNA (miRNA) target prediction, the present study quantitatively demonstrates that the miRNA targeting characteristic of mutually exclusive expression between miRNAs and target genes is formed by mammalian evolution. This study also revealed quantitatively that human miRNAs prefer targeting genes with intermediate levels of expression and that the preference has been formed by mammalian evolution.

Free Research Field

進化生物学