2016 Fiscal Year Final Research Report
Prediction of human migration by H. pylori and and evolutionary analysis of the virulence
| Project/Area Number |
26440198
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Oita University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | Helicobacter pylori / 人類移動 / 病原性 / 系統解析 / 集団解析 |
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| Outline of Final Research Achievements |
This study focused on two subjects: (1) prediction of prehistoric human migration in Asia using H. pylori, and (2) exploration of new virulence factors in H. pylori. As for the subject (1), we found that there are unique H. pylori strains in Okinawa and that divergence date of Okinawa specific strains is estimated as 20,000 to 30,000 B.C. This result suggests that human population might have reached to Ryukyu islands before Jomon era. As for the subject (2), we compared genomic sequences of H. pylori isolated from gastric cancer and MALT lymphoma patients. As the results, we found loci where amino acid frequency differs significantly between the two disease groups in major virulence genes cagA and vacA.
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| Free Research Field |
分子進化
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