Theoretical and empirical studies for compensatory molecular evolution

2016 Fiscal Year Final Research Report

• Project/Area Number: 26440202
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Evolutionary biology
• Research Institution: Hokkaido University (2015-2016); National Institute of Genetics (2014)
• Principal Investigator: Osada Naoki 北海道大学, 情報科学研究科, 准教授 (70416270)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 分子進化

Outline of Final Research Achievements

Compensatory molecular evolution refers to the process where the fixation of multiple mutation that are singly deleterious maintain organismal fitness by compensating their effects. In this research project, we mainly focus on the compensatory weak selection model, where the fixation of slightly advantageous mutations follow the fixation of slightly deleterious mutations in a variety of molecular systems, including protein-protein interaction and gene expression.

Free Research Field

集団遺伝学，分子進化学