2016 Fiscal Year Final Research Report
Search for advanced inhibitors of YUCCA, a key enzyme in auxin biosynthesis
| Project/Area Number |
26450069
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Plant protection science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMADA Yukihisa 横浜市立大学, 木原生物学研究所, 教授 (30300875)
SOENO Kazuo 独立行政法人農業・食品産業技術総合研究機構, 近畿中国四国農業研究センター (50392006)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | オーキシン / 生合成阻害剤 / YUCCA / ローリンテロール / 紅藻ソゾ / ハロゲン化合物 |
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| Outline of Final Research Achievements |
From the results of screening of own chemical library (including about 200 samples) using both YUCCA enzyme inhibition test (in vitro) and plant growth test with Arabidopsis seeds (in vivo), it was found that several extracts from the red algal genus Laurencia and sea hares, together with 2-APB known as a TRP channel inhibitor, exhibited strong inhibitory effects. Bioassay-guided fractionation of these active extracts resulted in the isolation of three halogenated laurane-type sesquiterpenes with different chemical structures from known YUCCA inhibitors. Among these active compounds, laurinterol and 2-APB showed stronger inhibitory activity than known inhibitors in the plant growth inhibition assay.
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| Free Research Field |
天然物有機化学
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