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2016 Fiscal Year Final Research Report

Huge number of secondary metabolism genes in fungal genomes: roles and regulation by environmental signal transduction pathways

Research Project

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Project/Area Number 26450109
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied microbiology
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Motoyama Takayuki  国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (70291094)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywordsイネいもち病菌 / 糸状菌ゲノム / 二次代謝 / 抗生物質 / シグナル伝達
Outline of Final Research Achievements

We found that TAS1, the tenuazonic acid biosynthetic gene of the rice blast fungus, codes for a new-type secondary metabolite biosynthetic enzyme, and involved in infection. We also found that environmental signals induce tenuazonic acid production via an epigenetic regulator and a transcription factor. Furthermore, we isolated a tenuazonic acid production-inducing compound from a chemical library. This compound induced production of secondary metabolites in other fungus, suggesting that there is a common mechanism in secondary metabolite production control.

Free Research Field

応用微生物学

URL: 

Published: 2018-03-22  

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