2016 Fiscal Year Final Research Report
Huge number of secondary metabolism genes in fungal genomes: roles and regulation by environmental signal transduction pathways
| Project/Area Number |
26450109
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Motoyama Takayuki 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (70291094)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | イネいもち病菌 / 糸状菌ゲノム / 二次代謝 / 抗生物質 / シグナル伝達 |
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| Outline of Final Research Achievements |
We found that TAS1, the tenuazonic acid biosynthetic gene of the rice blast fungus, codes for a new-type secondary metabolite biosynthetic enzyme, and involved in infection. We also found that environmental signals induce tenuazonic acid production via an epigenetic regulator and a transcription factor. Furthermore, we isolated a tenuazonic acid production-inducing compound from a chemical library. This compound induced production of secondary metabolites in other fungus, suggesting that there is a common mechanism in secondary metabolite production control.
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| Free Research Field |
応用微生物学
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