2016 Fiscal Year Final Research Report
The role of bacterial toxin-antitoxin genes on biofim formation
| Project/Area Number |
26450110
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied microbiology
|
|---|
| Research Institution | Tokyo Institute of Technology |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | バイオフィルム |
|---|
| Outline of Final Research Achievements |
Biofilm is a structure in which microorganisms are present at high density on the interface and solid surface together with extracellular polysaccharides etc. In this application, we studied the bacterial toxin - antitoxin (TA) gene system playing an important role in biofilm formation and acquisition of resistance to antibiotics using molecular biology techniques. As a result, it was suggested that the function of the toxin gene overlapped in a substantial part and contributed to biofilm formation. Furthermore, it was revealed that the expression of the gene involved in biofilm formation is differentially regulated following the activation of the toxin gene.
|
| Free Research Field |
微生物学
|
