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2016 Fiscal Year Annual Research Report

MRI analysis of olfactory neurocircuits that discriminate odor and pheromone signals

Research Project

Project/Area Number 26450129
Research InstitutionKumamoto University

Principal Investigator

吉永 壮佐  熊本大学, 大学院生命科学研究部(薬), 講師 (00448515)

Project Period (FY) 2014-04-01 – 2017-03-31
Keywords匂い / フェロモン / 脳・神経 / MRI / 嗅覚 / 嗅球 / 副嗅球
Outline of Annual Research Achievements

【研究目的】多くの動物は、種の保存や生命の危機回避において、嗅覚を通じて外界から様々な情報を得ている。フェロモンや匂い物質といった化学物質がその情報の担い手であり、情動や行動、生理的変化を引き起こす。研究代表者らは、連携研究者との共同研究のもと、メスマウスの性行動を誘発するペプチド性フェロモンESP1について、物質同定、受容体、性行動に至る一連の構造機能解析を展開してきた。本研究は、これらの知見を発展させ、性行動を誘引するフェロモンや匂いを識別する神経伝達経路をMRIによって包括的に明らかにし、可視化することを目的とする。

【研究実績】ジャコウジカのオスから分泌され、メスを誘引する匂い物質について、マウス脳内における匂い刺激応答を、機能的MRI手法の1つであるBOLD法により捉えることに成功した。1分間隔の繰り返し匂い刺激に呼応して周期的に信号変化が生じる脳内部位を抽出する解析手法を確立し、これを適用することにより、応答部位を同定した。嗅覚伝導路である梨状皮質に加えて、脳深部の領域である外側視床下部や扁桃体にも応答が見られた。また、通常、MRI法において動物は麻酔下において撮像するが、麻酔下動物では捉えられない嗅覚刺激応答を観測するため、覚醒下の動物においてもMRI撮像できる手法の技術開発を進めた。

  • Research Products

    (14 results)

All 2017 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (9 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] An optimized slice-GRAPPA reconstruction method to reduce leakage artifacts in small-animal multiband imaging.2017

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Takeda, M., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 25 Pages: 3844-3844

    • Peer Reviewed
  • [Journal Article] A BOLD analysis of the olfactory perception system in the mouse whole brain, using independent component analysis.2017

    • Author(s)
      Funatsu, H., Hayashi, F., Yoshinaga, S., Takeda, M., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 25 Pages: 5363-5363

    • Peer Reviewed
  • [Journal Article] Development of an awake mouse MRI method using soft immobilization for a cryogenic probe system.2016

    • Author(s)
      Nakata, E., Kusanagi, S., Kimura, K., Araki, R., Takeda, M., Yoshinaga, S., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 24 Pages: 1757-1757

    • Peer Reviewed
  • [Journal Article] An iterative reconstruction method for dual-band EPI in small-animal studies.2016

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 24 Pages: 3242-3242

    • Peer Reviewed
  • [Journal Article] Image-based phase correction for dual-band EPI with slice-GRAPPA using point-by-point procedures in k-space.2016

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., and Terasawa, H.
    • Journal Title

      Proc. Intl. Soc. Mag. Reson. Med.

      Volume: 24 Pages: 4315-4315

    • Peer Reviewed
  • [Presentation] An optimized slice-GRAPPA reconstruction method to reduce leakage artifacts in small-animal multiband imaging.2017

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Takeda, M., and Terasawa, H.
    • Organizer
      25th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, U.S.A.
    • Year and Date
      2017-04-22 – 2017-04-27
    • Int'l Joint Research
  • [Presentation] A BOLD analysis of the olfactory perception system in the mouse whole brain, using independent component analysis.2017

    • Author(s)
      Funatsu, H., Hayashi, F., Yoshinaga, S., Takeda, M., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Organizer
      25th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Hawaii Convention Center, Honolulu, Hawaii, U.S.A.
    • Year and Date
      2017-04-22 – 2017-04-27
    • Int'l Joint Research
  • [Presentation] 独立成分解析を利用したマウス嗅覚受容システムの BOLD 解析2017

    • Author(s)
      舩津大嗣、林芙優、吉永壮佐、杠直哉、草薙俊輔、武田光広、寺沢宏明
    • Organizer
      ISMRM日本支部第1回学術集会
    • Place of Presentation
      脳情報通信融合研究センター、大阪
    • Year and Date
      2017-02-23 – 2017-02-24
  • [Presentation] Optimization of the awake mouse MRI method using mouse clothes for a cryogenic coil system.2016

    • Author(s)
      Nakata, E., Kusanagi, S., Kimura, K., Araki, R., Takeda, M., Yoshinaga, S., and Terasawa, H.
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ、埼玉
    • Year and Date
      2016-09-10
  • [Presentation] Detecting the olfactory responses in the mouse whole brain using a cryogenic probe.2016

    • Author(s)
      Funatsu, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., Takeda, M., and Terasawa, H.
    • Organizer
      第44回日本磁気共鳴医学会大会
    • Place of Presentation
      大宮ソニックシティ、埼玉
    • Year and Date
      2016-09-10
  • [Presentation] fMRI analyses of the mouse olfactory perception system using a cryogenic probe.2016

    • Author(s)
      Funatsu, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., Takeda, M., and Terasawa, H.
    • Organizer
      The XXVIIth ICMRBS (International Conference on Magnetic Resonance in Biological Systems)
    • Place of Presentation
      Kyoto International Conference Center, Kyoto, Japan
    • Year and Date
      2016-08-22 – 2016-08-25
    • Int'l Joint Research
  • [Presentation] Development of an awake mouse MRI method using soft immobilization for a cryogenic probe system.2016

    • Author(s)
      Nakata, E., Kusanagi, S., Kimura, K., Araki, R., Takeda, M., Yoshinaga, S., and Terasawa, H.
    • Organizer
      24th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore
    • Year and Date
      2016-05-09 – 2016-05-12
    • Int'l Joint Research
  • [Presentation] Image-based phase correction for dual-band EPI with slice-GRAPPA using point-by-point procedures in k-space.2016

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., and Terasawa, H.
    • Organizer
      24th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore
    • Year and Date
      2016-05-09 – 2016-05-12
    • Int'l Joint Research
  • [Presentation] An iterative reconstruction method for dual-band EPI in small-animal studies.2016

    • Author(s)
      Toyoda, H., Yoshinaga, S., Yuzuriha, N., Kusanagi, S., and Terasawa, H.
    • Organizer
      24th ISMRM (International Society for Magnetic Resonance in Medicine) annual meeting
    • Place of Presentation
      Suntec Singapore Convention & Exhibition Centre, Singapore
    • Year and Date
      2016-05-09 – 2016-05-12
    • Int'l Joint Research

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Published: 2018-01-16  

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