Development of the vaccine for food allergy using degradated allergens

2016 Fiscal Year Final Research Report

• Project/Area Number: 26450151
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: Yoshida Tadashi 東京農工大学, (連合)農学研究科(研究院), 准教授 (20302911)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アレルギー / 免疫寛容 / ワクチン / 分解アレルゲン

Outline of Final Research Achievements

The aim of this study is to demonstrate the efficacy and safety of the vaccine for food allergy using degradated allergens.
We first prepared the degradated allergen by treating the allergen under the acid condition. We then evaluated the antigenicity and T cell stimulatory activity of the degradated allergen, and showed that the treatment could be used to prepare the degradated allergen having T cell stimulatory activity with reduced antigenicity. We finally showed that the oral administration of the degradated allergen to food allergy model mice inhibited the induction of food allergy triggered by the subsequent intake of the intact allergen. Our results demonstrated that the efficacy and safety of the food allergy vaccine.

Free Research Field

農学