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2016 Fiscal Year Final Research Report

Molecular design of novel phenylpropanoid-derived anti-amyloidal compounds using quantum-dot probes

Research Project

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Project/Area Number 26450153
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Food science
Research InstitutionShinshu University

Principal Investigator

NAKAMURA Soichiro  信州大学, 役員等, 理事 (00105305)

Co-Investigator(Renkei-kenkyūsha) TOKURAKU Kiyotaka  室蘭工業大学, 工学系研究科, 准教授 (00332106)
HIGUCHI Keiichi  信州大学, 学術研究院医学系, 教授 (20173156)
Project Period (FY) 2014-04-01 – 2017-03-31
Keywords量子ドットプローブ / フェニルプロパノイド / 脂肪酸エステル / 抗アミロイド性新素材 / 生体系における効果
Outline of Final Research Achievements

With the progress of super aging society, diseases caused by deposition of amyloid fibrils are becoming a social problem. In this study, I focused on phenylpropanoids that are widely distributed in nature, and tried to create novel active compounds linked with sugar chains or fatty acid chains of different chain length and hydrophobicity. And then, structure-function relationship was investigated to enhance their anti-amyloidal activities. For measurement of anti-amyloidal activity, amyloidgenic peptide-linked quantum dots was used as a probe. In addition, experiments using drosophila and nematode were also conducted. As a result, ferulic acid ester and caffeic acid ester synthesized by lipase were proposed as a novel anti-amyloidal compound.

Free Research Field

食品化学

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Published: 2018-03-22  

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