Mechanisms underlying physiological functions of phytochemicals via proteo-hormesis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26450156
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: University of Hyogo (2015-2016); Kyoto University (2014)
• Principal Investigator: Murakami Akira 兵庫県立大学, 環境人間学部, 教授 (10271412)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: ファイトケミカル / 作用機構 / 抗炎症作用 / 適応応答 / ゼルンボン / クルクミン / ホルミシス / ストレス

Outline of Final Research Achievements

Phytochemical, including polyphenols, have been shown to exhibit various physiological functions. For instance, there is ample evidence that phytochemicals have anti-obesity and anti-cancer effects in cellular and rodent models while the mechanisms underlying those functions are still unclear. In this study, a novel and unique mechanism has been found, i.e., several phytochemicals may exhibit proteo-stress properties towards cellular proteins, which may activate protein quality control systems and thereby showing anti-inflammatory functions in a cellular model.

Free Research Field

食品機能学