2016 Fiscal Year Final Research Report
Preventive effect of food-derived bioactive compounds with anti-angiogenic and autophagy activities on aging.
| Project/Area Number |
26450159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 抗老化 / 血管新生 / オートファジー / FoxO3a / 運動器 / 脳機能 / 老齢疾患 |
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| Outline of Final Research Achievements |
We screened autophagy activating effect of food-derived anti-angiogenic compounds and found that carnosic acid (CA) in rosemary has the effect. To evaluate the anti-aging effect of CA, CA was orally administrated to senescence-accelerated mice prone 8 (SAMP8) for a year. CA group of SAMP8 showed a lower death rate compare to control group. In histological analyses, liver and kidney of CA group were better than those of control group. In behavior tests, CA group showed better results than control group suggesting CA prevented brain function. We found that the molecular mechanism by which CA exerts anti-aging effect is attribute to activation of FoxO3a, a transcription factor relating longevity.
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| Free Research Field |
食品機能学
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