2016 Fiscal Year Final Research Report
Study on the dietary components which affect incretin secresion by regulating the function of plasma membrane in enteroendocrine cells
| Project/Area Number |
26450162
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | GPR120 / インクレチン |
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| Outline of Final Research Achievements |
In this study, we examined how the sphingolipids, polyphenols, or polysaccharide in food affect the function of plasma membrane on enteroendocrine cells, We focused on the receptor of long-chain fatty acid, GPR120, and developed a new method to assay fatty acid/ GPR120 signaling employing TGF alpha- shedding assay. The method was convenient and showed high quantity. Using this method, we found several new ligand and molecules which affect alpha linolenic acid/ GPR120 signaling.
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| Free Research Field |
生化学
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