2016 Fiscal Year Final Research Report
Study on cellular senescence-induced changes in vitamin C transport/accumulation activity and its regulation mechanism
| Project/Area Number |
26450163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Prefectural University of Hiroshima |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | ビタミンC / アスコルビン酸 / 細胞老化 / 活性酸素 / 細胞内輸送 / 細胞内蓄積 / 線維芽細胞 / レスベラトロール |
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| Outline of Final Research Achievements |
Vitamin C (VC) is transported and accumulated into human cells and plays various physiological roles, but the relationship between the intracellular vitamin C transport/accumulation activity and cellular senescence has not been fully understood yet. In this study, we demonstrated that both VC transport/accumulation activity and the expression of VC-transporter were increased in old cells compared with young cells, and VC was effective in decreasing intracellular oxidative stress especially in senescent cells. Furthermore, we also found the possibility that resveratrol was involved in the regulation VC transport/accumulation activity. From these results, we show the importance of VC supplementation in senescent cells, and identified the new regulating factor for the VC transport/accumulation.
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| Free Research Field |
農芸化学
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