Molecular mechanisms of gastric defense and intestinal immunity involving calpains

2017 Fiscal Year Final Research Report

• Project/Area Number: 26450172
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: HATA Shoji 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (10392375)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: カルパイン / 胃腸防御

Outline of Final Research Achievements

There are complex defense systems in the gastrointestinal mucosa, usually exposed to external stresses. Our previous study revealed that intracellular protease complex G-calpain (heterodimer of calpain 8 and calpain 9) expressed specifically in the gastrointestinal tract is involved in stress-responsive gastric mucosal protection, and intestinal immunity via regulation of Th17 cell differentiation, although these mechanisms are unknown. This study suggested that G-calpain acts on gastric mucosal defense by regulating migration and proliferation of mucus-secreting cells and negative regulation of gastric acid secretion, and that G-calpain activity regulates, or is regulated by, epithelial adhesion of intestinal bacteria in the intestine.

Free Research Field

細胞内タンパク質分解