2017 Fiscal Year Final Research Report
Molecular mechanisms of gastric defense and intestinal immunity involving calpains
Project/Area Number |
26450172
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Tokyo Metropolitan Institute of Medical Science |
Principal Investigator |
HATA Shoji 公益財団法人東京都医学総合研究所, 生体分子先端研究分野, 主席研究員 (10392375)
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Keywords | カルパイン / 胃腸防御 |
Outline of Final Research Achievements |
There are complex defense systems in the gastrointestinal mucosa, usually exposed to external stresses. Our previous study revealed that intracellular protease complex G-calpain (heterodimer of calpain 8 and calpain 9) expressed specifically in the gastrointestinal tract is involved in stress-responsive gastric mucosal protection, and intestinal immunity via regulation of Th17 cell differentiation, although these mechanisms are unknown. This study suggested that G-calpain acts on gastric mucosal defense by regulating migration and proliferation of mucus-secreting cells and negative regulation of gastric acid secretion, and that G-calpain activity regulates, or is regulated by, epithelial adhesion of intestinal bacteria in the intestine.
|
Free Research Field |
細胞内タンパク質分解
|