2016 Fiscal Year Final Research Report
Research on the fish cytosolic LPS sensor and its mechanism
| Project/Area Number |
26450288
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Aquatic life science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | トラフグ / NLR / カスパーセ１ / インフラマソーム / メダカ / LPS |
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| Outline of Final Research Achievements |
To discover the first sensor to recognize LPS in the cytosol, the genes consisted of inflammasome were cloned in Fugu (Takifugu rubripes). These genes were significantly induced in the kidney cells stimulated with nigericin, silica and alum. Furthermore, medaka (Oryzias latipes) NLR-PYD and Caspase-1 genes were also cloned and the caspase-1 activity were demonstrated and confirmed. These suggest that there is probably an inflammasome-like activation system in fish.
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| Free Research Field |
水圏生命科学
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