2016 Fiscal Year Final Research Report
Involvement of nuclear and mitochondrial genome on immune function and reproductive performance in dairy cow
| Project/Area Number |
26450372
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Animal production science
|
|---|
| Research Institution | Obihiro University of Agriculture and Veterinary Medicine |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Keywords | 繁殖性 / 免疫機能 / 一塩基多型 / ゲノム |
|---|
| Outline of Final Research Achievements |
Toll-like receptor 4 (TLR4) and TLR2 are receptor for LPS that is released from gram-negative bacteria. In postpartum dairy cows, inflammation diseases such as metritis and mastitis suppress reproductive performance. The present study is to examine the relationships among SNPs for TLR4 and TLR2 and reproductive performance and immune functions. TLR4 SNP affect the production of cytokine, apoptosis and migration of immune cells. In addition, TLR4 SNP affect ovarian function such as ovulation. Moreover, TLR2 SNP influence follicular cell function (steroid production). These data suggest that SNPs for TLR4 and TLR2 are associated with reproductive performance and immune function.
|
| Free Research Field |
生殖科学
|
