2016 Fiscal Year Final Research Report
Exploration of oocyte maturation inducing factor by analysis of time-specific regulation of ADAM17 substrate specificity during follicular development and ovulation process.
| Project/Area Number |
26450381
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal production science
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| Research Institution | Prefectural University of Hiroshima |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 卵胞発育 / 排卵 / 卵成熟 / ADAM17 |
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| Outline of Final Research Achievements |
Previous our study showed the importance that ADAM17 shed the EGF-like factors (Amphiregulin; AREG，Epiregulin; EREG), as known the ovulation and oocyte maturation inducing factor. Since ADAM17 alters its substrate specificity in other cells type, we investigate the mechanism of follicular development and ovulation by the enzyme. In follicular development phase, we investigate that ADAM17 controls secretion of TGF-β in mice. Since previous studies showed that TGF-b induced expression of FSH receptor during follicular development, we assumed that the ADAM17 regulates selection of dominant follicle. In ovulation phase, we reveal that ADAM17 activity is up-reuglated by Neurotensin, which induce sustainable activation of ERK1/2 in cumulus cells and meiotic and cytoplasmic maturation of oocyte.
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| Free Research Field |
動物生産A
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