Improving meat production by fundamental research on myogenic differentiation

2016 Fiscal Year Final Research Report

• Project/Area Number: 26450391
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Animal production science
• Research Institution: Kyushu University
• Principal Investigator: Nakamura Mako 九州大学, 農学研究院, 准教授 (80452746)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 筋細胞分化 / 食肉科学 / 畜産物

Outline of Final Research Achievements

Muscle regeneration is initiated by activation of muscle stem cells, known as satellite cells, which are adjacent to the basal lamina around the proximal region of each myofiber.We previously showed that Semaphorin 3A (Sema3A) expression was induced when quiescent muscle became activated satellite cells (ASCs). However, how Sema3A regulates genes in the early phase of ASCs remains unclear. In this study, we investigated whether Sema3A signaling can regulate the early phase of ASCs. We showed that expression of the myogenic proliferation regulatory factors Pax7 and Myf5 was decreased in myoblasts transfected with Sema3A siRNA. Emerin was also regulated by Sema3A in ASCs.

Free Research Field

筋細胞学