2016 Fiscal Year Final Research Report
Anti-tumor mechanism of soluble form of sialic acid-recognizing protein, Siglec-9
| Project/Area Number |
26450398
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Tottori University |
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Principal Investigator |
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| Research Collaborator |
TAKEUCHI Takashi
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 疾患モデルマウス / 病態 / 腫瘍 / シアル酸認識レクチン / ムチン |
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| Outline of Final Research Achievements |
It was revealed that proliferation and malignant transformation of MUC1-positive tumor were prevented in the transgenic mice expressing a soluble form of sialic acid-binding immunoglobulin-like lectin 9 (sSiglec-9). In addition, it was suggested that this anti-tumor mechanism indirectly acted through the immune system of the host. On the other hand, sSiglec-9 acivated a proliferation of MUC16-positive tumor rather than inhibited, surprisingly. According to the above results, it was shown Siglec-9 interacted with the mucin expressed in tumor and to participate in a tumor proliferation and malignant transformation. These knowledge make the beginning to found the molecular targeted therapy for cancers through Siglec-9.
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| Free Research Field |
農学
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