Roles of MARCKS in platelets, smooth muscle and endothelial cells in haemostasis and thrombosis

2017 Fiscal Year Final Research Report

• Project/Area Number: 26450407
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Kagoshima University
• Principal Investigator: SHIRAISHI Mitsuya 鹿児島大学, 農水産獣医学域獣医学系, 准教授 (20383656)
• Co-Investigator(Renkei-kenkyūsha): MIYAMOTO Atsushi 鹿児島大学, 農水産獣医学域獣医学系, 教授 (70219806)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Keywords: MARCKS / 血管内皮細胞 / 血管平滑筋細胞 / 血小板

Outline of Final Research Achievements

We studied the role of MARCKS protein in endothelial cells, smooth muscle cells, and platelets. In endothelial cells, MARCKS protein was involved in cell proliferation, cell migration, and nitric oxide production. Furthermore, participation of MARCKS in abnormal cell functions of diabetes or methylmercury intoxication model animals was suggested. In addition, MARCKS was expressed in smooth muscle cells and platelets, and the role of MARCKS in these cells was indicated.

Free Research Field

基礎獣医学