2016 Fiscal Year Final Research Report
Establishment of DLA-88 typing for canine cancer peptide vaccine
| Project/Area Number |
26450434
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Veterinary medical science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
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| Research Collaborator |
Moritomo Tadaaki 日本大学, 生物資源学部・獣医免疫学研究室, 教授
Miyamae Jiro 日本大学, 生物資源学部・獣医免疫学研究室, 大学院生
TAKESHIMA Shin-nosuke 理化学研究所, 分子ウイルス学特別研究ユニット, 研究員
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | DLA-88型 / 犬メラノーマ / melan-A / TRP-2 / survivin / 犬がんペプチドワクチン |
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| Outline of Final Research Achievements |
Because the lung metastasis of cancer that is induced depending on the effect of psychological stress was able to be prevented by a peptide-vaccine in mouse model, the development project of a peptide-vaccine using dog is advanced as the new strategy for treatment by which targeted the prevention of the recurrence and metastasis of progressive cancer. This study succeeded in finding of the canine peptide epitope (melan-A、TRP-2、survivin) for inducible specific cytotoxic T lymphocytes (CTLs),1) and had arrived in the detection of the those peptides-restricted specific canine MHC class I (DLA-88) types identified by DLA-88 gene typing.2)
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| Free Research Field |
免疫学、獣医病理学
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