2016 Fiscal Year Final Research Report
Gliotransmitter release and its protective effects in spinal astrocytes
| Project/Area Number |
26450440
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Soichiro 北海道大学, 大学院獣医学研究科, 助教 (50596864)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | アストロサイト / アデノシン / 硫化水素 / 脊髄 / グリア伝達物質 |
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| Outline of Final Research Achievements |
Production and release mechanisms of adenosine and hydrogen sulfide (H2S), which are known to be neuroprotective agents, were examined in the cultured spinal astrocytes. Under the low Ca2+ conditions, ATP released by astrocytes was extracellularly degraded to adenosine, resulting in the increase in extracellular adenosine level. The astrocytic CBS (H2S synthase) expression was suggested to be controlled/maintained by the neurons. Adenosine and H2S affect cellular functions via the activation of receptors and ion channels. Under the ischemic conditions, it is suggested that the change in adenosine and H2S production and releases by the low Ca2+ and/or neuronal death is involved in disease onset and progression.
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| Free Research Field |
獣医薬理学
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