2016 Fiscal Year Final Research Report
Exploring a novel therapeutic agent for the treatment of traumatic brain injury based on the function of glial cells
| Project/Area Number |
26450447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Keywords | 外傷性能損傷 / アストロサイト / 浮腫 / ミクログリア / グリア活性化 / 生理学 / 神経化学 |
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| Outline of Final Research Achievements |
Cerebral edema is an important complication of traumatic brain injury (TBI) and astrocyte swelling appears to be primarily responsible for the edema. We focused on the activation of glial cells such as astrocytes and microglia in this swelling and searched for inhibitors for the purpose of exploring novel neuroprotective / therapeutic agents. We found that acetate suppressed glial cell activation and reduced edema. Acetate may offer these effects through an anti-oxidative mechanism. The obtained results suggest the possibility of acetate as an effective therapeutic agent for brain edema after TBI.
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| Free Research Field |
農学
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