Innate immue response through glycolipids by adenovirus-vector

2016 Fiscal Year Final Research Report

• Project/Area Number: 26450450
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrative animal science
• Research Institution: Azabu University
• Principal Investigator: Okamoto Mariko 麻布大学, 獣医学部, 講師 (30415111)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: アデノウイルスベクター / 糖脂質 / 自然免疫 / 炎症性サイトカイン / 遺伝子治療

Outline of Final Research Achievements

Adenovirus vectors are widely used in cancer gene therapies, and be expected to be effective also in gene therapy in veterinary medicine. However, there is a problem that adenovirus vectors induce innate immune responses more than necessary, such as inducing high production of inflammatory cytokines after administration. It has been suggested that glycosphingolipids on the cell membrane regulate TLR signals, but it has not been cleared whether or not these glycosphingolipids are involved in activation of innate immune response by adenoviral vector administration. In this study, we examined the involvement of glycosphingolipids in activation of innate immune response by adenoviral vector administration.

Free Research Field

獣医免疫・獣医遺伝子導入制御