Elucidation of patterns and regulatory mechanism of undifferentiated spermatogonial motion in mouse testis

2016 Fiscal Year Final Research Report

• Project/Area Number: 26450453
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrative animal science
• Research Institution: Tohoku University (2015-2016); National Institute for Basic Biology (2014)
• Principal Investigator: Hara Kenshiro 東北大学, 農学研究科, 准教授 (60551546)
• Co-Investigator(Renkei-kenkyūsha): YOSHIDA Shosei 自然科学研究機構, 基礎生物学研究所, 教授 (60294138)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Keywords: 精巣 / 精子幹細胞 / 精原細胞 / 細胞運動

Outline of Final Research Achievements

The purpose of this　study　is　to　understand　motion　patterns　and　regulatory　mechanisms　of　stem　and　differentiating cells in mouse seprmatogenesis. In this study, we found that stem cells move actively and randomly, while differentiating cells are less motile. We also found that heterogeneous motion is likely to be generated by two mechanisms: syncytial formation (unique biological event in spermatogenesis) and cell state-dependent motion property. Future analysis for molecular mechanisms of stem/differentiating cell motion and biological significance of stem cell motion will be needed. During this support, we published a paper in Cell Stem Cell (Hara etal., 2014).

Free Research Field

繁殖生物学